Corticorelin
 | |
| Clinical data | |
|---|---|
| AHFS/Drugs.com | International Drug Names |
| ATC code | V04CD04 (WHO) |
| Identifiers | |
| CAS Number | 79804-71-0 |
| PubChem (CID) | 16132344 |
| UNII |
305OE8862Y  Y |
| Chemical and physical data | |
| Formula | C205H339N59O63S |
| Molar mass | 4670.31 g/mol |
| (verify) | |
Corticorelin (INN) is a diagnostic agent. It is a synthetic form of human corticotropin-releasing hormone (hCRH).[1]
The corticorelin stimulation test helps to differentiate between the etiologies of adrenocorticotropic hormone (ACTH)-dependent hypercortisolism. It is used to evaluate the status of the pituitary-adrenal axis in the differentiation of a pituitary source from an ectopic source of excessive ACTH secretion.
- If corticorelin injection increases plasma levels of ACTH and cortisol, a diagnosis of Cushing's disease is achieved (ACTH of pituitary origin).
- If corticorelin injection leads to little or no response in plasma levels of ACTH or cortisol, a diagnosis of ectopic ACTH syndrome is confirmed.
See also
References
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