Galactoside O-acetyltransferase
| Galactoside O-acetyltransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 2.3.1.18 | ||||||||
| CAS number | 9029-94-1 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / EGO | ||||||||
| |||||||||
| Thiogalactoside acetyltransferase | |
|---|---|
| Identifiers | |
| Organism | |
| Symbol | lacA |
| Entrez | 945674 |
| RefSeq (Prot) | NP_414876 |
| UniProt | P07464 |
Galactoside O-acetyltransferase (also known as thiogalactoside transacetylase) is an enzyme encoded by the lacA gene in E. coli. The protein plays a role in cell detoxification.[1]
Reaction
It catalyzes the following reaction:
acetyl-CoA + beta-D-galactoside → CoA + 6-acetyl-beta-D-galactoside
Structure
In E. coli, thiogalactoside transacetylase is a dimer. Its monomer consists of 202 amino acid residues. The protein has a molecular weight of 22,671.[2]
The amino terminus of the protein is heterogenous because the initiator methionine is only partially cleaved. The protein is found in the cell cytoplasm and contains a highly hydrophobic segment in its center.
See also
References
- ↑ "Thiogalactoside transacetylase of the lactose operon as an enzyme for detoxification.". 1976.
- ↑ "The amino acid sequence of thiogalactoside transacetylase of Escherichia coli.". Biochimie. 67 (1): 101–8. 1985. doi:10.1016/s0300-9084(85)80235-2. PMID 3922433.
This article is issued from Wikipedia - version of the 4/2/2016. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.