PRMT3

PRMT3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2FYT, 3SMQ, 4HSG, 4QQN, 4RYL
Identifiers
Aliases	PRMT3, HRMT1L3, protein arginine methyltransferase 3
External IDs	MGI: 1919224 HomoloGene: 24255 GeneCards: PRMT3
Gene ontology Molecular function • protein-arginine N-methyltransferase activity • metal ion binding • methyltransferase activity • histone-arginine N-methyltransferase activity • protein-arginine omega-N asymmetric methyltransferase activity • transferase activity • protein binding Cellular component • cytosol • ribosome • cytoplasm Biological process • protein methylation • methylation • regulation of transcription, DNA-templated • negative regulation of protein ubiquitination • peptidyl-arginine N-methylation • histone arginine methylation • peptidyl-arginine methylation, to asymmetrical-dimethyl arginine Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	10196	71974
Ensembl	ENSG00000185238	ENSMUSG00000030505
UniProt	O60678	Q922H1
RefSeq (mRNA)	NM_001145166 NM_001145167 NM_005788	NM_133740
RefSeq (protein)	NP_005779.1	NP_598501.1
Location (UCSC)	Chr 11: 20.39 – 20.51 Mb	Chr 7: 49.78 – 49.86 Mb
PubMed search	[1]	[2]
Wikidata

Protein arginine N-methyltransferase 3 is an enzyme that in humans is encoded by the PRMT3 gene.^[3][4]

Model organisms

Model organisms have been used in the study of PRMT3 function. A conditional knockout mouse line, called Prmt3^{tm1a(EUCOMM)Wtsi[13][14]} was generated as part of the International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists.^[15][16][17]

Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion.^[11][18] Twenty seven tests were carried out on mutant mice and seven significant abnormalities were observed.^[11] Fewer than predicted homozygous mutant mice survived until weaning due to hydrocephaly. The remaining tests were carried out on both heterozygous and homozygous mutant adult mice. Male heterzygous mice had a decreased respiratory quotient. Homozygous females had decreased body weight, length and bone mineral density. Homozygous males had abnormal peripheral blood lymphocyte counts and homozygotes of both sex had eye abnormalities.^[11]

Interactions

PRMT3 has been shown to interact with RPS2.^[19]

References

Further reading

External links

• PRMT3 human gene location in the UCSC Genome Browser.
• PRMT3 human gene details in the UCSC Genome Browser.

PDB gallery
1f3l: CRYSTAL STRUCTURE OF THE CONSERVED CORE OF PROTEIN ARGININE METHYLTRANSFERASE PRMT3  1wir: Solution structure of the C2H2 zinc finger domain of the protein arginine N-methyltransferase 3 from Mus musculus  2fyt: Human HMT1 hnRNP methyltransferase-like 3 (S. cerevisiae) protein