Polyaminopropyl biguanide
 | |
| Names | |
|---|---|
| Other names
Polyamine-propyl-biguanidine | |
| Identifiers | |
133029-32-0  | |
| Abbreviations | PAPB |
| ECHA InfoCard | 100.118.649 |
| Properties | |
| (C5H11N5)n | |
| Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). | |
verify (what is  ?) | |
| Infobox references | |
Polyaminopropyl biguanide (PAPB) is a disinfectant and a preservative used for disinfection on skin and in cleaning solutions for contact lenses. It is also an ingredient in many deodorant bodysprays. It is a polymer or oligomer where biguanide functional groups are connected by hexyl hydrocarbon chains, with varying chain lengths. PAPB is specifically bactericidal at very low concentrations (10 mg/l) and is also fungicidal.
Biocidal activity
It has a unique method of action: the polymer strands are incorporated into the bacterial cell membrane, which disrupts the membrane and reduces its permeability, which has a lethal effect to bacteria. It is also known to bind to bacterial DNA, alter its transcription, and cause lethal DNA damage.[1]
Disinfectant
PAPB solutions are sold for use as a general disinfectant solution to be applied onto skin. As it is not cytotoxic, it can be applied directly into wounds.[2] It is also not irritating like more traditional disinfectants such as alcohols (ethanol, isopropanol) and oxidizers (iodine).
Contact lens solution
A contact lens solution containing polyaminopropyl biguanide in combination with a borate buffer has been patented.[3] The solution is disinfecting and preservative and has a broad spectrum of bactericidal and fungicidal activity at low concentrations coupled with very low toxicity when used with soft-type contact lenses.[4]
Clothing treatment
Purista is a PHMB-based preparation that is added to socks to slow the development of body odor. By adding microbicides to textiles in such a manner that they are slowly released to the local environment, bacteria and fungi sensitive to the microbicide can be killed in proximity to the textiles; this may slow down processes that depend on the microorganisms, such as the development of body odor.
See also
- Antibiotic Resistance
- Polyhexanide, a related biguanide disinfectant
- Benzalkonium chloride
- Stearalkonium chloride
- Ethylenediaminetetraacetic acid
- Triclosan
- Thiomersal
References
- ↑ Allen; White, GF; Morby, AP; et al. (2006). "The response of Escherichia coli to exposure to the biocide polyhexamethylene biguanide". Microbiology (Reading, England). 152 (4): 989–1000. doi:10.1099/mic.0.28643-0. PMID 16549663.
- ↑ Gerit D. Mulder, Joseph P. Cavorsi and Daniel K. Lee (2007). "Polyhexamethylene Biguanide (PHMB): An Addendum to Current Topical Antimicrobials". Wounds. 19 (7): 173–182.
- ↑ Ogunbiyi et al. US 4758595
- ↑ Josefa Velasco, Javier Bermudez (1996). "Comparative study of the microbial flora on contact lenses, in lens cases, and in maintenance liquids". Contact Lens and Anterior Eye. 23 (2): 55–58. doi:10.1016/0892-8967(96)00004-1.