SCGB3A1

SCGB3A1

Identifiers

SCGB3A1, HIN-1, HIN1, LU105, PnSP-2, UGRP2, secretoglobin family 3A member 1

External IDs

MGI: 1915912 HomoloGene: 14160 GeneCards: SCGB3A1

Gene ontology
Molecular function	• cytokine activity
Cellular component	• extracellular region • extracellular exosome • extracellular fluid
Biological process	• negative regulation of cell growth • regulation of cell proliferation • positive regulation of myoblast fusion
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse


92304


68662


ENSG00000161055


ENSMUSG00000064057


Q96QR1


Q920D7

RefSeq (mRNA)


NM_052863


NM_054037 NM_170727

RefSeq (protein)


NP_443095.2


NP_473378.1

Location (UCSC)

Chr 5: 180.59 – 180.59 Mb

Chr 11: 49.66 – 49.67 Mb

PubMed search

^[1]

^[2]

View/Edit Human

View/Edit Mouse

Secretoglobin family 3A member 1 is a protein that in humans is encoded by the SCGB3A1 gene.^[3]^[4]^[5]

References

↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ Niimi T, Keck-Waggoner CL, Popescu NC, Zhou Y, Levitt RC, Kimura S (Oct 2001). "UGRP1, a uteroglobin/Clara cell secretory protein-related protein, is a novel lung-enriched downstream target gene for the T/EBP/NKX2.1 homeodomain transcription factor". Mol Endocrinol. 15 (11): 2021–36. doi:10.1210/me.15.11.2021. PMID 11682631.
↑ Krop IE, Sgroi D, Porter DA, Lunetta KL, LeVangie R, Seth P, Kaelin CM, Rhei E, Bosenberg M, Schnitt S, Marks JR, Pagon Z, Belina D, Razumovic J, Polyak K (Aug 2001). "HIN-1, a putative cytokine highly expressed in normal but not cancerous mammary epithelial cells". Proc Natl Acad Sci U S A. 98 (17): 9796–801. doi:10.1073/pnas.171138398. PMC 55532. PMID 11481438.
↑ "Entrez Gene: SCGB3A1 secretoglobin, family 3A, member 1".

Further reading

Porter D, Lahti-Domenici J, Torres-Arzayus M, et al. (2003). "Expression of high in normal-1 (HIN-1) and uteroglobin related protein-1 (UGRP-1) in adult and developing tissues.". Mech. Dev. 114 (1-2): 201–4. doi:10.1016/S0925-4773(02)00056-4. PMID 12175512.
Reynolds SD, Reynolds PR, Pryhuber GS, et al. (2003). "Secretoglobins SCGB3A1 and SCGB3A2 define secretory cell subsets in mouse and human airways.". Am. J. Respir. Crit. Care Med. 166 (11): 1498–509. doi:10.1164/rccm.200204-285OC. PMID 12406855.
Niimi T, Copeland NG, Gilbert DJ, et al. (2003). "Cloning, expression, and chromosomal localization of the mouse gene (Scgb3a1, alias Ugrp2) that encodes a member of the novel uteroglobin-related protein gene family.". Cytogenet. Genome Res. 97 (1-2): 120–7. doi:10.1159/000064067. PMID 12438750.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Krop I, Maguire P, Lahti-Domenici J, et al. (2003). "Lack of HIN-1 methylation in BRCA1-linked and "BRCA1-like" breast tumors.". Cancer Res. 63 (9): 2024–7. PMID 12727813.
Bin LH, Nielson LD, Liu X, et al. (2003). "Identification of uteroglobin-related protein 1 and macrophage scavenger receptor with collagenous structure as a lung-specific ligand-receptor pair.". J. Immunol. 171 (2): 924–30. doi:10.4049/jimmunol.171.2.924. PMID 12847263.
Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
Fackler MJ, McVeigh M, Evron E, et al. (2004). "DNA methylation of RASSF1A, HIN-1, RAR-beta, Cyclin D2 and Twist in in situ and invasive lobular breast carcinoma.". Int. J. Cancer. 107 (6): 970–5. doi:10.1002/ijc.11508. PMID 14601057.
Tisserand P, Fouquet C, Barrois M, et al. (2004). "Lack of HIN-1 methylation defines specific breast tumor subtypes including medullary carcinoma of the breast and BRCA1-linked tumors.". Cancer Biol. Ther. 2 (5): 559–63. doi:10.4161/cbt.2.5.511. PMID 14614327.
Marchetti A, Barassi F, Martella C, et al. (2004). "Down regulation of high in normal-1 (HIN-1) is a frequent event in stage I non-small cell lung cancer and correlates with poor clinical outcome.". Clin. Cancer Res. 10 (4): 1338–43. doi:10.1158/1078-0432.CCR-1174-03. PMID 14977834.
Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites.". Protein Sci. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMC 2286551. PMID 15340161.
Krop I, Player A, Tablante A, et al. (2005). "Frequent HIN-1 promoter methylation and lack of expression in multiple human tumor types.". Mol. Cancer Res. 2 (9): 489–94. PMID 15383627.
Shigematsu H, Suzuki M, Takahashi T, et al. (2005). "Aberrant methylation of HIN-1 (high in normal-1) is a frequent event in many human malignancies.". Int. J. Cancer. 113 (4): 600–4. doi:10.1002/ijc.20622. PMID 15472908.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Krop I, Parker MT, Bloushtain-Qimron N, et al. (2005). "HIN-1, an inhibitor of cell growth, invasion, and AKT activation.". Cancer Res. 65 (21): 9659–69. doi:10.1158/0008-5472.CAN-05-1663. PMID 16266985.
Yang Q, Kiernan CM, Tian Y, et al. (2007). "Methylation of CASP8, DCR2, and HIN-1 in neuroblastoma is associated with poor outcome.". Clin. Cancer Res. 13 (11): 3191–7. doi:10.1158/1078-0432.CCR-06-2846. PMID 17545522.
Wu Q, Lothe RA, Ahlquist T, et al. (2007). "DNA methylation profiling of ovarian carcinomas and their in vitro models identifies HOXA9, HOXB5, SCGB3A1, and CRABP1 as novel targets.". Mol. Cancer. 6: 45. doi:10.1186/1476-4598-6-45. PMC 1964763. PMID 17623056.

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