Signal peptidase II
| Signal peptidase II | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 3.4.23.36 | ||||||||
| CAS number | 171715-14-3 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Signal peptidase II (EC 3.4.23.36, premurein-leader peptidase, prolipoprotein signal peptidase, leader peptidase II, premurein leader proteinase) is an enzyme.[1][2][3] This enzyme catalyses the following chemical reaction
- Release of signal peptides from bacterial membrane prolipoproteins including murein prolipoprotein. Hydrolyses -Xaa-Yaa-Zaa-(S,diacylglyceryl)Cys-, in which Xaa is hydrophobic (preferably Leu), and Yaa (Ala or Ser) and Zaa (Gly or Ala) have small, neutral sidechains
This enzyme is present in bacterial inner membranes.
References
- ↑ Dev, I.K.; Ray, P.H. (1990). "Signal peptidases and signal peptide hydrolases". J. Bioenerg. Biomembr. 22: 271–290. doi:10.1007/bf00763168. PMID 2202720.
- ↑ Zhao, X.-J.; Wu, H.C. (1992). "Nucleotide sequence of the Staphylococcus aureus' signal peptidase II (lsp) gene". FEBS Lett. 299: 80–84. doi:10.1016/0014-5793(92)80105-p. PMID 1544479.
- ↑ Sankaran, K.; Wu, H.C. (1995). "Bacterial prolipoprotein signal peptidase". Methods Enzymol. 248: 169–180. doi:10.1016/0076-6879(95)48014-5. PMID 7674920.
External links
- Signal peptidase II at the US National Library of Medicine Medical Subject Headings (MeSH)
This article is issued from Wikipedia - version of the 5/23/2016. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.